Human Disease


Small RNA

CPSS 2.0

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Development of large-scale sequencing technique leads to an increasing production of datasets, among which small RNA sequencing data is one of the most straightforward types of NGS data to analyze. Lots of small RNA analysis tools have been developed accordingly. Such as Chimira (Vitsios and Enright, 2015), focusing on discovering modifications, WapRNA (Zhao, et al., 2011), a web server used to map miRNA and predict their targets, Oasis (Capece, et al., 2015), a web application in searching miRNAs, predicting targets and functional analysis, And our published work, CPSS 1.0 (Zhang, et al., 2012), integrated 10 species could process ncRNA expression and functional analysis for single and paired samples. But these tools are insufficient to provide users with comprehensive statistical and functional analysis of complicated ncRNA datasets generated from vast species. Besides, with decreased sequencing cost, there has been an increasing need to test ncRNA from multi-group or huge amount of samples in order to discover differently or even specifically expressed ncRNA under particular physiology, pathology or experimental conditions. Accompanied with comprehensive functional analysis, most potential cluster of ncRNA could be targeted before follow-up experiments. To meet these demands, we updated CPSS 1.0 to CPSS 2.0, including 1) modified workflow achieved by analysis of multi-samples and groups datasets, 2) 38 more species added into the platform and updated software and database to provide up-to-date information, 3) strengthened visualization benefitted users in the usage of CPSS 2.0 and their analysis results. We believe CPSS 2.0 could assist users in a comprehensive and effective manner with their projects.

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